https://www.theguardian.com/science/2017/jan/25/pancreatic-cancer-drugs-trial-combination-extends-survival

 

Trial finds combination of pancreatic cancer drugs extends survival

Campaigners hail ‘monumental leap forward’ in treatment of most lethal form of cancer, which kills 8,800 Britons each year

 Microscopic view of pancreatic cancer cells. Photograph: Stocktrek Images Inc/Alamy Stock Photo

Cancer campaigners are hailing a “monumental leap forward” in pancreatic cancer treatment after a new drug trial significantly extended survival from what is the most lethal form of the disease.

The clinical trial found that 29% of patients given a combination of two chemotherapy drugs lived for at least five years compared with 16% who received the one chemotherapy drug that is still the NHS’s standard treatment.

The results are important because they could lead to an improvement in the prospects for people who develop pancreatic cancer, which has the lowest survival rates among the 21 most common forms of the disease and kills 8,800 Britons a year. Only one in 100 people survive for 10 or more years after their diagnosis.

“These results are a monumental leap forward in pancreatic cancer treatment. We believe this could herald a true step change in the treatment of this tough cancer, offering substantially more patients who have had surgery the chance to live for longer and, crucially, without significant added side-effects,” said Leanne Reynolds, head of research at the charity Pancreatic Cancer UK.

About 10,000 people are diagnosed with pancreatic cancer each year in the UK. However, the apparent breakthrough may only benefit the 800 who have surgery. The cancer is too advanced in most of the other 9,200 cases for surgery to be worthwhile.

Four in five patients are only diagnosed when the cancer has reached an advanced stage, and in 46% of cases only after they have presented as an emergency at an A&E unit. Survival rates have barely improved for 40 years, in contrast to some other forms of the disease. It is the fifth most common cause of cancer death in the UK.

The ESPAC-4 (European study group for pancreatic cancer) trial involved 732 patients from 92 hospitals in England, Scotland, Wales, Germany, France and Sweden. Of those given both gemcitabine and capecitabine, 28.8% survived for at least five years, compared with just 16.3% who received only gemcitabine.

Pancreatic Cancer UK and the researchers behind the findings are now urging the NHS to replace gemcitabine with the combination as the standard treatment for the one in 12 sufferers of the disease who undergo a resection of their pancreas.

“This is one of the biggest ever breakthroughs prolonging survival for pancreatic cancer patients,” said Prof John Neoptolemos of Liverpool University, who lead the team of researchers.

“When this combination becomes the new standard of care it will give many patients living with the disease valuable months and even years.” The two drugs taken together extend median overall survival from 25 and a half months for those on gemcitabine alone to 28 months, according to the study, which has been published in the Lancet.

“The difference in short-term survival may seem modest, but improvement in long-term survival is substantial for this type of cancer,” added Neoptolemos.

Meanwhile, separate research has also brought good news about lung cancer, which has the second worst survival rates among the commonest forms of cancer.

The number of people surviving for at least a year after diagnosis rose from 31% to 38% between 2010-2015, according to the NHS’s latest audit of the quality of care patients receive. Experts in the disease welcomed the increase, which is mainly the result of earlier diagnosis.

Ian Woolhouse, the audit’s senior clinical lead, said it was “very encouraging” that one-year survival had improved in what is the UK’s second most common form of cancer after breast cancer.

His team noted other progress too in how the NHS treats patients, including the fact that 60% of patients now receive some for of anti-cancer treatment. They analysed the records of 43,000 people diagnosed with lung cancer in 2015.

However, they voiced concern about the persistent “wide and unacceptable variation in standards of care” provided by NHS trusts and boards across England, Wales, Scotland and Guernsey. Only 57% of patients are seen by a specialist lung cancer nurse, for example, even though the target for that is 90%.

Dr Jesme Fox, medical director of the Roy Castle Lung Cancer Foundation, said: “We are pleased to see this encouraging increase in patient survival. However, there is much still to do to ensure that lung cancer patients are diagnosed as early as possible and are able to access best practice treatment and care.”

https://www.theguardian.com/science/2017/jan/25/pancreatic-cancer-drugs-trial-combination-extends-survival

 

https://www.theguardian.com/science/2016/feb/25/scientists-discover-pancreas-cancer-is-four-separate-diseases

 

Scientists discover pancreatic cancer is four separate diseases

Breakthrough paves the way for more accurate treatment of a cancer fewer than 20% of sufferers survive more than year after diagnosis

 Microscopic view of pancreatic cancer cells. Photograph: Alamy

Scientists have discovered pancreatic cancer is four separate diseases, paving the way for more accurate diagnosis and treatment.

Researchers said the findings were the launch pad to investigate new treatments because doctors currently have little insight into which will be most effective for patients.

Around 8,800 people are diagnosed with pancreatic cancer in the UK each year and just 20% of adults survive more than a year after being diagnosed.

Fewer than 5% of sufferers survive after five years and only 1% are still alive after 10 years.

The study, carried out by a team of researchers at the University of Glasgow, looked at 456 pancreatic cancer tumours and found the disease could be classified as one of four different sub-types: squamous, pancreatic progenitor, immunogenic and ADEX.

Prof Sean Grimmond, who led the study, said there were already cancer drugs available or in development that could target parts of the “damaged machinery” which led to pancreatic cancers.

For example, some strains of the disease were associated with mutations normally linked to colon cancer or leukaemia, for which experimental drugs are being used to treat, he said.

Grimmond said: “This study demonstrates that pancreatic cancer is better considered as four separate diseases, with different survival rates, treatments and underlying genetics.

“Knowing which sub-type a patient has would allow a doctor to provide a more accurate prognosis and treatment recommendations.”

The charity Pancreatic Cancer UK described the results, published in the journal Nature, as “incredibly exciting”.

Its head of research Leanne Reynolds said the findings meant that in the future “the right patients can be given the right treatment at the right time”.

She said: “This is crucial for people with pancreatic cancer, because the disease is difficult to diagnose, is often diagnosed terribly late, and just 4% of people live for five years or more after diagnosis.

“If we can predict more accurately which treatment would be most effective for each patient, we can ensure patients have the best chance of living for as long as possible, as well as possible.”

Dr Emma Smith, from Cancer Research UK, said: “Identifying different types of pancreatic cancer and revealing the disease’s complexity is an important step towards finding more effective treatments.

“This will help to ensure patients are given the therapies that are most likely to help. Improving survival for people with pancreatic cancer is one of our top priorities, and we urgently need more research like this if we’re going to beat this disease in the future.”

https://www.theguardian.com/science/2016/feb/25/scientists-discover-pancreas-cancer-is-four-separate-diseases

 

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6 Warning Signs of Pancreatic Cancer, No 4 is Shocking 11:11

Published on Sep 29, 2016
Descriptions of Warning symptoms of Pancreatic Cancer:
It accounts for about 3 percent of all cancers in the United States, but 7 percent of cancer deaths.
Pancreatic cancer begins in the tissues of your pancreas, a pear-shaped organ located behind the lower part of your stomach
Pancreatic cancer is difficult to detect early and it typically spreads rapidly, affecting other parts of the body. This is why it is called a silent disease and you must get cancer pancreas treatment.

Here are the top 6 early warning signs of pancreatic cancer that you must know.

1, Jaundice.
It is common for people with pancreatic cancer to experience jaundice, characterized by yellowing of the eyes or skin. Jaundice can also cause itchiness on the hands and feet, especially the palms and soles.
Any size of tumor located in the head of the pancreas can lead to irregular bile (a yellowish-brown fluid released by your liver to aid digestion) flowing from the gallbladder into the small intestine. This causes excess buildup of bilirubin in the blood, one of the main causes of jaundice.

2, Abdominal and Lower Back Pain.
Abdominal as well as back pain are also common symptoms in patients with pancreatic cancer. Usually, the sharp pain is felt in the upper abdomen, which gradually radiates toward the back.
Many patients also report the pain is more severe at night and that they get slight relief from the pain by bending forward.
If you are experiencing persistent, mild to moderate abdominal pain, consult a doctor or pancreatic cancer clinical trials. Most cases of pancreatic cancer are diagnosed in patients visiting the emergency room complaining of severe abdominal pain.

3, Nausea and Vomiting.
Nausea followed by vomiting is another sign of pancreatic cancer. As the tumor grows, it can block some portions of the digestive tract, which hampers the overall digestion process.
Along with nausea and vomiting, you may also experience heartburn and acid reflux.
If these symptoms tend to worsen after eating and it is becoming difficult for you to eat anything without throwing up, consult your doctor and get best pancreatic cancer treatment.
In advanced cases of pancreatic cancer, surgery may be required to bypass the blockage and improve digestion.

4, Unexplained Weight Loss.
Unexplained weight loss is another noticeable warning sign of different types of cancer, including pancreatic cancer.
Weight loss often occurs when a tumor spreads to nearby organs and impairs their functioning. This affects proper digestion of nutrients and also leads to poor appetite.
Also, due to lack of pancreatic enzymes aiding digestion, dietary fats start passing through the body undigested, which in turn causes weight loss. Furthermore, the cancer cells compete with healthy cells for nutrients you must find a pancreatic cancer therapy.


5, Greasy or Light-Colored Stool.
Stools of people suffering from pancreatic cancer have some distinct characteristics. The stools may become large, pale, oily, floating and smelly as the growing tumor prevents the pancreas from releasing its digestive enzymes.
As the color and consistency of your stool says a lot about your health, any kind of bowel changes should be reported to your doctor.

6, Changes in Urine Color.
Along with changes in your stools, you may also notice changes in your urine color, despite drinking enough fluid throughout the day. Your urine may become darker and take on an orange, amber or brown shade.
A growing pancreatic tumor can cause bile to get blocked and not released from your body in the way that it should be. Too much bilirubin in the body can get into your urine and make it dark in appearance. At times, there also may be traces of blood in your urine.

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Pancreatic Cancer - About Pancreatic Cancer 6:20

Uploaded on Oct 7, 2010
A diagnosis of pancreatic cancer can be overwhelming, it raises many questions: What is the pancreas? Where is it? What does it do? What is pancreatic cancer? What happens now? What tests will I have? Who will treat me? What research is being done? Where do I go for support?

We're here to help you find the answers to your questions: http://pancreaticcancersupport.com.au/

Most importantly, you will discover that you are not alone.

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https://www.theguardian.com/society/pancreas-cancer

https://www.theguardian.com/science/2018/jul/30/substance-in-cannabis-could-boost-pancreatic-cancer-treatments

 

Substance in cannabis 'could boost pancreatic cancer treatments'

Scientists say cannabidiol could extend patients’ lives by a matter of years

 Cannabis plants. Photograph: Robyn Beck/AFP/Getty Images

A substance found in cannabis plants might boost treatments for patients with pancreatic cancer, research in mice has suggested.

Cannabidiol, or CBD, is not psychoactive, meaning it does not produce feelings of being high in those who take it. It is extracted from hemp plants and is legal in the UK, although a CBD product must be licensed before it can be advertised as having health benefits. At present, there are no licensed CBD-only medicines in the UK, but it is being used in a number of clinical trials, including for treating psychosis.

Now scientists say CBD could boost the effect of drugs used to treat pancreatic cancer – a disease with a bleak prognosis. Only about 5% of those with the condition survive for five years, and around 80% die within a year of diagnosis.

“It is very aggressive, so it is very important to find new therapies for this cancer,” said Dr Riccardo Ferro, first author of the research from Queen Mary University of London.

While the latest study was conducted in mice, the team behind the research say that if the results are replicated in humans, the treatment could result in many patients having their lives extended by a matter of years.

Among the subsequent experiments, the team took mice that had been genetically modified to develop pancreatic cancer and split them into four groups.

Ten mice were given CBD, eight were given the chemotherapy drug gemcitabine, seven were given both drugs, and nine were given a placebo.

Mice in the placebo group lasted for just under 19 days on average, while those in the CBD group lived for just over 25 days and those in the gemcitabine group for almost 28 days.

When the two drugs were combined, the effect was even more dramatic, extending the average survival to almost 53 days after starting treatment.

The team say the CBD blocks the receptors produced by the GPR55 gene, preventing them from interacting with other substances that promote the growth and multiplication of the cancer cells. What’s more, they found CBD hinders the development of resistance to gemcitabine.

However, others cautioned that as the study involved only a small number of mice, it is unclear whether the effects of CBD would also be seen in humans, and that it is unknown whether CBD might interact with other drugs taken by those with pancreatic cancer.

Dr Catherine Pickworth from Cancer Research UK said it was encouraging that researchers were looking into new ways to tackle pancreatic cancer, but that clinical trials are crucial and until there is evidence that CBD will help humans with the cancer, patients should be cautious.

“We don’t advise patients to use cannabis oil or any alternative therapies to treat cancer,” she said. “Some ‘natural’ remedies can interfere with medical treatment, so it’s really important that patients speak to their doctor before making any decisions.”

Both THC and cannabis oil are controlled substances and classified under schedule 1, meaning that in the UK they are not recognised as having medical benefits. However, the home secretary, Sajid Javid, recently said he was looking into making cannabis oil easier to be prescribed in the UK.

A combination of CBD and THC called Sativex is currently licensed for use in people with multiple sclerosis, although patients in England struggle to get it on the NHS.

Prof David Nutt, a former government adviser on drugs, welcomed the new study, saying: “This is one drop in what I suspect will become a torrent of research findings showing therapeutic value of cannabinoids in a range of cancers.

“I am pleased progress is now being made but very sad for the thousands of people who have died prematurely from treatable cancer because of the lies national governments and the World Health Organization have told about cannabinoids having no medical value, and thus restricting research by placing them in schedule 1.”

https://www.theguardian.com/science/2018/jul/30/substance-in-cannabis-could-boost-pancreatic-cancer-treatments

 

Patrick Swayze ♥ - The Truth - A Barbara Walters Special ♥ [Part 5/5] HQ 7:59

Uploaded on Jan 9, 2009
Swayze was diagnosed with pancreatic cancer in late January 2008, and has been undergoing chemotherapy and other treatments at the Stanford University Medical Center. A March 5, 2008 Reuters article reports that Swayze "has a very limited amount of disease, and he appears to be responding well to treatment thus far".

Swayze's doctor has confirmed the actor has been diagnosed with pancreatic cancer, but insists he's not as close to death as reports suggest. Specifically, Swayze was diagnosed with a type of pancreatic tumor called Intraductal Papillary Mucinous Neoplasm (IPMN). In early May 2008, it was widely reported that in a number of tabloids that Swayze had undergone surgery to remove part of his stomach after the spread of the cancer, and that he had rewritten his will, transferring his property to his wife.

In a statement made on May 28, Swayze said that he continues to respond well to treatment at Stanford University Medical Center. In late May 2008 he was seen at a Los Angeles Lakers basketball game, his first public appearance since his diagnosis. In 2008 Swayze was treated with Cyberknife radiotherapy cancer treatment.

In late July 2008, six months after allegedly being given just weeks to live by medical experts, Swayze was seen in Los Angeles LAX airport appearing healthy. When asked about his condition, he told reporters "I'm cooking. I'm a miracle dude, I don't know why".


Swayze appeared on the ABC, NBC, and CBS simulcast of Stand Up to Cancer in September 2008, to appeal to the general public for donations for the initiative.

Swayze said to a standing ovation, "I dream that the word 'cure' will no longer be followed by the words 'it's impossible'. Together we can make a world where cancer no longer means living with fear, without hope, or worse". After the show ended, Swayze lingered onstage and talked to other cancer survivors; executive producer Laura Ziskin said, "He said a beautiful thing: 'I'm just an individual living with cancer.' That's how he wants to be thought of. He's in a fight, but he's a fighter".


Swayze has denied claims made by tabloids that the cancer has spread to his liver. However, in his interview with Barbara Walters which aired in January of 2009, Swayze revealed that he had a "tiny little mass" in his liver.

What is the Sign & Symptoms of Pancreatic Cancer? Pancreatic Cancer Facts 16:38

Published on May 31, 2016
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Pancreatic Cancer questions answered by Dr. Daniel Rayson 52:28

Uploaded on Feb 9, 2012
Dr. Daniel Rayson, medical oncologist, answers questions about pancreatic cancer at the Craig's Cause Pancreatic Cancer Society support group for pancreatic cancer patients and caregivers. The support group meets in Halifax, Nova Scotia, on the first Tuesday of every month, 7-9 p.m.. For more information, visit www.craigscause.ca

Pancreatic Cancer | How to Diagnose Pancreatic Cancer-Healthy Wealthy 3:21

Published on Sep 26, 2016
How to Diagnose Pancreatic Cancer
Pancreatic cancer is an aggressive type of cancer with a poor prognosis that spreads quickly and causes a lot of pain in its later stages — the gland's digestive enzymes spill into surrounding tissues and destroy them. However, in the early stages, pancreatic cancer can cause few (if any) symptoms, so it's difficult to diagnose, which is why it's so deadly. Early diagnosis is important because there are more treatment options available.

Fine Needle Aspiration Thyroid Nodule (graphic) 6:49

Published on Jul 17, 2012
Learn about the thyroid gland and a thyroid nodule. Also, view a step-by-step guide through a fine needle aspiration (FNA) procedure and what to expect after the test. To learn more visit, http://bit.ly/PRIf2L

Thyroid Nodules: Assessment and Management (Webinar) 45:39

Published on Jun 5, 2013
http://www.nyheadneck.org
In this 45 minute recorded Webinar, Dr. Catherine Sinclair, Director of the Division of Head and Neck Surgery at St. Luke's and Roosevelt Hospitals in New York, presents a comprehensive look at the assessment, diagnosis and overall approaches to the treatment of thyroid nodules.

Thyroid Nodules & Thyroid Cancer: What You Need to Know | #UCLAMDCHAT 1:01:48

Published on Jan 26, 2016
UCLA endocrine surgeons Michael Yeh, MD, and Masha Livhits, MD, discuss the latest strategies to diagnose thyroid nodules; how to avoid surgery, if possible; and best practices for treating thyroid cancer #UCLAMDCHAT
www.uclahealth.org/uclamdchat

6 Thyroid Pain Symptoms You Should Not Ignore 10:11

Published on Aug 23, 2016
Descriptions of thyroid pain symptoms:
About 4.6 percent of the United States population suffers from underactive thyroid . The risk for developing hypothyroidism and infertility is higher in women over age 50 and postpartum females.
If you have multiple signs and symptoms of this problem, ask your doctor to check your thyroid hormone levels and get treatment of thyroid.
Here are the signs and symptoms that you have an underactive thyroid.

1. Unexplained Weight Gain
Weight gain without any change in diet or physical activity may indicate low levels of thyroid hormones. These hormones help regulate basal metabolism and thermogenesis as well as the metabolism of fats and glucose.
An underactive thyroid contributes to a lower metabolic rate, which may cause excess weight gain.
If you have unexplained weight gain, it is essential to consult your doctor to determine the exact cause and get hypothyroidism treatment weight loss.

2. Dry and Flaky Skin
If you are following your usual beauty and skin care regimen and haven’t changed any of the products you use but your skin is dry and itchy, it could be a symptom of hypothyroidism or thyroid dry skin.
The change in skin texture and appearance can be due to reduced blood circulation, one of the side effects of having low thyroid hormones.
In addition, a slowed metabolism due to low thyroid hormone production can reduce sweating. Without proper sweating, the skin becomes dry and flaky.
As these skin signs are rather nonspecific and often subtle, people tend to ignore them or attribute them to other causes. It is best to consult your doctor to see if there is an underlying health condition causing these skin changes.

3. Muscle Soreness and Pain
People suffering from hypothyroidism often experience muscle weakness, pain, stiffness, or cramping. There may also be general joint pain.
Low metabolism disrupts how your body burns energy, which can affect how your muscles feel after doing your regular exercises. Low thyroid often increases inflammation that may be contributing to your muscle and joint pain.
In fact, about 40 percent of the hypothyroid patients had predominantly sensory signs of a sensorimotor axonal neuropathy early in the course of thyroid disease.

4. Hair Loss
hypothyroidism hair loss and Proper functioning of the thyroid gland is essential for the development and maintenance of the hair follicles, and an underactive thyroid can result in significant changes in hair growth and texture. It may also affect eyebrows and body hair.
The thyroid hormones thyroxine (T4) and triiodothyronine (T3) modulate several aspects of hair anatomy, from the hair growth cycle to the hair’s pigmentation.
If you are worried about hair loss and other hair-related issues, see your doctor to get your thyroid checked.

5. Constant Fatigue and Tiredness
Fatigue and extreme tiredness are very common in people who have an underactive thyroid. When low thyroid hormones flow through the blood, cells do not function properly, leading to less energy, fatigue and constant tiredness. These symptoms persist even after getting proper sleep and rest.
A 2012 study published in the European Journal of Endocrinology notes that autoimmune hypothyroidism patients had significantly higher levels of fatigue as compared with differentiated thyroid carcinoma patients health thyroid.

6. Menstrual and Fertility Problems
Women with hypothyroidism may experience menstrual as well as fertility problems. Thyroid hormones have a great influence on menstruation, thyroid pregnancy, lactation and even uterine involution after childbirth.
In fact, the study puts emphasis on the assessment of thyroid function in all patients with menstrual disorders to avoid unnecessary interventions like curettage and hysterectomy.
Infertility can also be due to undiagnosed thyroid conditions.
For any change in menstrual pattern as well as problems becoming pregnant, it is important to get your thyroid checked.

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